Inhibitors of CYP2D6: Potential pharmacokinetic interaction increased tolterodine concentrations. If you take pramlintide with medicines that speed up the movement of food through your stomach, your pramlintide may not work as well. Medicines like tolterodine tartrate extended-release capsules can cause blurred vision, dizziness, and drowsiness. Patients should be informed that antimuscarinic agents such as tolterodine tartrate extended-release capsules may produce the following effects: blurred vision, dizziness, or drowsiness. Patients should be advised to exercise caution in decisions to engage in potentially dangerous activities until the drug's effects have been determined.
Read the Patient Information that comes with Tolterodine Tartrate Tablets before you start using it and each time you get a refill. There may be new information. This leaflet does not take the place of talking with your doctor about your condition or your treatment. Only your doctor can determine if treatment with Tolterodine Tartrate Tablets is right for you. Store Detrol at room temperature, between 59 and 86 degrees F 15 and 30 degrees C. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Detrol out of the reach of children and away from pets. St John's Wort: May decrease the serum concentration of CYP3A4 Substrates. Management: Consider an alternative for one of the interacting drugs. Some combinations may be specifically contraindicated. Consult appropriate manufacturer labeling.
You have trouble emptying your bladder also called "urinary retention". Detrol, like other antimuscarinic drugs, should be used with caution in patients with decreased gastrointestinal motility. DETROL LA did not help the symptoms of when studied in children. The primary efficacy assessment was change in mean number of incontinence episodes per week at week 12 from baseline. Secondary efficacy measures included change in mean number of micturitions per day and mean volume voided per micturition at week 12 from baseline.
You are allergic to DETROL LA or to any of its ingredients. Overdosage with tolterodine tartrate extended-release capsules can potentially result in severe central anticholinergic effects and should be treated accordingly. To treat incontinence, doctors inject botulinum toxin into the bladder muscle. This is done with a needle that is inserted via a long tube called a cystoscope that goes up into the bladder. Tolterodine belongs to the group of medicines called antispasmodics. It helps decrease muscle spasms of the bladder and the frequent urge to urinate caused by these spasms.
No dose adjustment is required when tolterodine and fluoxetine are coadministered. Do not increase your dose or take this medication more often than directed. Your condition will not improve any faster and your risk of serious side effects may be increased. PO 2 mg once daily. Always take Detrusitol exactly as your doctor has told you. Among the tales, Bozeman says, is a woman who was dancing at her wedding and suddenly there was a puddle on the floor.
On airplanes, be especially careful not to overdo the coffee, tea, alcohol, and soft drinks. Also, try to book an aisle seat near a lavatory. One percent of patients treated with Tolterodine Tartrate Tablets discontinued treatment due to dry mouth. The sums of unbound serum concentrations of tolterodine and 5-HMT are only 25% higher during the interaction. Use with caution in patients receiving therapy for angle-closure glaucoma. Distribution: Tolterodine is highly bound to plasma proteins, primarily α 1-acid glycoprotein. The frequency of discontinuation due to adverse events was highest during the first 4 weeks of treatment. Seven percent of patients treated with Tolterodine Tartrate Tablets 2 mg bid discontinued treatment due to adverse events versus 6% of placebo patients. The most common adverse events leading to discontinuation of Tolterodine Tartrate Tablets were dizziness and headache. No substantial differences in safety relative to younger adults. 1 23 See Absorption: Special Populations, under Pharmacokinetics. Medicines are sometimes prescribed for conditions that are not in the patient information leaflet. The difference between Tolterodine Tartrate Tablets and placebo was statistically significant. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Use: For the treatment of overactive bladder OAB with symptoms of urge urinary incontinence, urgency, and frequency What other drugs will affect tolterodine? N-dealkylated hydroxy tolterodine were significantly higher 10 to 30 fold in renally impaired patients as compared to the healthy volunteers. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time each day. The dosage is based on your medical condition especially and disease response to treatment, and other you may be taking. DETROL should not be administered during nursing. Three percent of patients treated with Tolterodine Tartrate Tablets 2 mg bid reported a serious adverse event versus 4% of placebo patients. Significant ECG changes in QT and QTc have not been demonstrated in clinical-study patients treated with Tolterodine Tartrate Tablets 2 mg bid. Table 5 lists the adverse events reported in 1% or more of the patients treated with Tolterodine Tartrate Tablets 2 mg bid in the 12-week studies. The adverse events are reported regardless of causality. vistaril
Tolterodine tartrate, USP is a white to off-white colored solid. In Phase 1, multiple-dose studies in which tolterodine immediate release 4 mg 2 mg bid was administered, serum concentrations of tolterodine and of the 5-hydroxymethyl metabolite were similar in healthy elderly volunteers aged 64 through 80 years and healthy young volunteers aged less than 40 years. In another Phase 1 study, elderly volunteers aged 71 through 81 years were given tolterodine immediate release 2 or 4 mg 1 or 2 mg bid. Mean serum concentrations of tolterodine and the 5-hydroxymethyl metabolite in these elderly volunteers were approximately 20% and 50% higher, respectively, than reported in young healthy volunteers. He or she will ask what kinds of fluids you drink and how much. Your doctor will also want to know how often you urinate, how much, and if you leak. It may help to write down these things in a What is a document? Peripheral Nervous: confusion, disorientation, memory impairment, hallucinations. Tolterodine Tartrate Tablets are available containing 1 mg or 2 mg of tolterodine tartrate, USP. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Tolterodine's effect on QT interval was found to correlate with plasma concentration of tolterodine. Ask your doctor or pharmacist for a list of these medicines, if you are not sure. National Association for Continence: "Overactive Bladder Syndrome. After oral administration, tolterodine is metabolized in the liver, resulting in the formation of the 5-hydroxymethyl derivative, a major pharmacologically active metabolite. The 5-hydroxymethyl metabolite, which exhibits an antimuscarinic activity similar to that of tolterodine, contributes significantly to the therapeutic effect. Both tolterodine and the 5-hydroxymethyl metabolite exhibit a high specificity for muscarinic receptors, since both show negligible activity or affinity for other neurotransmitter receptors and other potential cellular targets, such as calcium channels. Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure as required. Gotta go all the time? This information should not be used to decide whether or not to take Detrol or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Detrol. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Detrol. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Detrol. OnabotulinumtoxinA: Anticholinergic Agents may enhance the anticholinergic effect of OnabotulinumtoxinA. rosuvastatin shop sydney rosuvastatin
Medicines like DETROL LA can cause blurred vision, dizziness, and drowsiness. Most women who develop overactive bladder are 45 to 60 years old. Many do not seek professional medical help due to embarrassment. The benefit of the treatment should be re-evaluated after 2 or 3 months. Tolterodine 2 mg twice daily as conventional tablets appears to be less effective than extended-release oxybutynin 10 mg once daily as extended-release tablets in reducing urinary symptoms in patients with overactive bladder. The clearance of orally administered tolterodine immediate release was substantially lower in cirrhotic patients than in the healthy volunteers. For patients with mild to moderate hepatic impairment Child-Pugh Class A or B the recommended dose for tolterodine tartrate extended-release capsules is 2 mg once daily. Sarilumab: May decrease the serum concentration of CYP3A4 Substrates. DETROL LA can be taken with or without food. CYP3A4 Inhibitors Moderate: May decrease the metabolism of CYP3A4 Substrates. Carcinogenicity studies with tolterodine were conducted in mice and rats. SD Pharmacokinetic Parameters of Tolterodine Extended-Release and its Active Metabolite 5-Hydroxymethyl Tolterodine in Healthy Volunteers Data presented as median range. Parameter dose-normalized from 8 to 4 mg for the single-dose data.
Of the 1120 patients who were treated in the four Phase 3, 12-week clinical studies of Tolterodine Tartrate Tablets, 474 42% were 65 to 91 years of age. HMT are devoid of any significant inhibitory potential regarding the other isoenzymes. Child-Pugh Class A or B is DETROL LA 2 mg once daily. This information is generalized and not intended as specific medical advice. Taking tolterodine with your heart medicine may affect your heart's rhythm may increase your risk of an irregular heartbeat, which may be life-threatening. Most people get enough potassium by eating a well-. If OAB is the problem, doctors typically suggest lifestyle adjustments that may help. DETROL could harm your unborn baby. The need to urinate even if you have just gone to the bathroom. What are possible side effects of Detrol? The microscopic examination of urine that also involves a number of tests to detect and measure various compounds that pass through the urine. epivir off patent epivir
Moderate. These medicines may cause some risk when taken together. Read all of this leaflet carefully before you start using this medicine. GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. WE CANNOT ACCEPT RESPONSIBILITY FOR ANY ERRORS IN THIS PROOF AFTER APPROVAL. Do not keep outdated medicine or medicine no longer needed. DETROL, 474 42% were 65 to 91 years of age. purchase careprost otc
CYP2D6 Inhibitors Strong: May decrease the metabolism of CYP2D6 Substrates. Nitroglycerin: Anticholinergic Agents may decrease the absorption of Nitroglycerin. Specifically, anticholinergic agents may decrease the dissolution of sublingual nitroglycerin tablets, possibly impairing or slowing nitroglycerin absorption. Nocturia means you have to get up a lot during the night to go to the bathroom. Medicines like Detrol can cause blurred vision, dizziness, and drowsiness. Do not drive, operate machinery, or do other dangerous activities until you know how Detrol affects you. Tolterodine may cause a condition that affects the rhythm QT prolongation. Fluoxetine is a selective serotonin reuptake inhibitor and a potent inhibitor of CYP2D6 activity. Food intake increases the bioavailability of tolterodine average increase 53% but does not affect the levels of the 5-hydroxymethyl metabolite in extensive metabolizers. This change is not expected to be a safety concern and adjustment of dose is not needed. HMT the major pharmacologically active metabolite. No special precautions for storage. With PTNS, you'll need a series of 12 treatments, scheduled about a week apart. You may need more than one treatment to keep seeing results. Gastrointestinal obstructive disorders: Use with caution in patients with decreased GI motility or gastrointestinal obstructive disorders ie, pyloric stenosis; may increase the risk of gastric retention. MiFEPRIStone: May increase the serum concentration of CYP3A4 Substrates. Metabolism for discussion of poor metabolizers. Hills CJ, Winter SA, Balfour JA. Tolterodine. Drugs. Variability in Metabolism and Drug-Drug Interactions. Advise patients to swallow ER capsule whole.
If you continue to have problems with dry after a couple of weeks, call your doctor. Then there was the elevator incident, one of life's most embarrassing moments. Dunn was standing on an elevator with a stranger when the urge hit. Crossing her legs didn't prevent the puddle on the floor. This medicine comes with a patient information insert. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand. The information contained in the Truven Health Micromedex products as delivered by Drugs. Following administration of a 5-mg oral dose of 14C-tolterodine solution to healthy volunteers, 77% of radioactivity was recovered in urine and 17% was recovered in feces in 7 days. Limit and alcohol intake. Do you have the problem only during the day or also at night? MedlinePlus Medical Encyclopedia: "Frequent or Urgent Urination. Detrol should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed. levothyroxine can i order visa
Have any stomach or intestinal problems. Taking many trips to the bathroom only to urinate just a little bit each time. Importance of women informing their clinician if they are or plan to become pregnant or plan to breast-feed. Your doctor will tell you how many Tolterodine Tartrate Tablets to take and when to take them. Oxatomide: May enhance the anticholinergic effect of Anticholinergic Agents. Some medicines can cause overactive bladder. Talk with your doctor about the medicines you're taking to find out if they could affect your bladder. But don't stop taking your medicine without talking to your doctor first. What are the symptoms? The review does not make recommendations about the use of these drugs. The effect of 200 mg daily dose of ketoconazole on the pharmacokinetics of tolterodine immediate-release was studied in 8 healthy volunteers, all of whom were poor metabolizers see for discussion of poor metabolizers. Dose reduction or discontinuation should be considered if CNS effects occur. Ipratropium Oral Inhalation: May enhance the anticholinergic effect of Anticholinergic Agents. Tolterodine tartrate extended-release capsules may cause allergic reactions that may be serious. Symptoms of a serious allergic reaction may include swelling of the face, lips, throat, or tongue. If you experience these symptoms, you should stop taking tolterodine tartrate extended-release capsules and get emergency medical help right away. Fosaprepitant: May increase the serum concentration of CYP3A4 Substrates. DETROL LA in nursing mothers. If you have not noticed any effect by then, talk to your doctor. Take tolterodine tartrate extended-release capsules exactly as prescribed. Your doctor will prescribe the dose that is right for you. Do not change your dose unless told to do so by your doctor. Tell your doctor if your condition persists or worsens. uker.info bactrim
Avoid doing things that may cause you to overheat, such as hard work or in hot weather, or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. If you overheat, quickly look for a place to cool down and rest. MedlinePlus Medical Encyclopedia: "Cystometry. This condition of unknown cause is characterized by pain in the bladder and pelvic region. No mutagenic or genotoxic effects of tolterodine were detected in a battery of in vitro tests, including bacterial mutation assays Ames test in 4 strains of Salmonella typhimurium and in 2 strains of Escherichia coli, a gene mutation assay in L5178Y mouse lymphoma cells, and chromosomal aberration tests in human lymphocytes. Tolterodine was also negative in vivo in the bone marrow micronucleus test in the mouse. In a study with 14C-tolterodine solution in healthy volunteers who received a 5 mg oral dose, at least 77% of the radiolabeled dose was absorbed. Tolterodine immediate-release is rapidly absorbed, and maximum serum concentrations C max typically occur within 1 to 2 hours after dose administration. Tolterodine Tartrate Tablets are associated with anticholinergic central nervous system CNS effects including dizziness and somnolence see . Patients should be monitored for signs of anticholinergic CNS effects, particularly after beginning treatment or increasing the dose. Tolterodine Tartrate Tablets should be used with caution in patients with myasthenia gravis, a disease characterized by decreased cholinergic activity at the neuromuscular junction. Renal impairment can significantly alter the disposition of tolterodine immediate-release and its metabolites.
Tolterodine Tartrate Tablets should be used with caution in patients being treated for narrow-angle glaucoma. Are you experiencing other symptoms? Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Blurred vision; constipation; dizziness; drowsiness; dry eyes; dry mouth; headache; indigestion; stomach pain. Liver impairment can significantly alter the disposition of tolterodine immediate-release. Who should not take DETROL? Gelnique tolterodine fesoterodine fumarate Toviaz trospium and . Oxytrol is available in a pill by prescription and in the form of the patch over the counter for women. Who should not take Tolterodine Tartrate Tablets? Inactive ingredients: ethylcellulose, gelatin, hydroxypropyl cellulose, hypromellose, iron oxide black, propylene glycol, shellac glaze, sugar spheres which contain sucrose and corn starch titanium dioxide, and triethyl citrate. Anon. Detrol LA and Ditropan XL for overactive bladder. Med Lett Drugs Ther. zovirax purchase now europe
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Discuss specific use of drug and side effects with patient as it relates to treatment. HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Weight gain 1%; peripheral edema postmarketing. Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Pfizer. Detrol tolterodine tartrate tablets prescribing information. New York, NY; 2008 Mar. You can take Detrol with or without food. casodex
These are not all the side effects with tolterodine tartrate extended-release capsules. For a complete list, ask your doctor or pharmacist. Besides the sudden, sometimes uncontrollable urge to urinate, overactive bladder symptoms include leakage. Urination is frequent, typically 13 or more times in 24 hours. Awakening two or three times during the night to urinate isn't unusual. Effect of Food: There is no effect of food on the pharmacokinetics of tolterodine extended release. BID, tolterodine 4 mg BID, and placebo. National Institute of Neurological Disorders and Stroke: "Neurological Diagnostic Tests and Procedures.
Cut back on drinks, such as coffee, tea, and sodas. Tolterodine Tartrate Tablets are contraindicated in patients with urinary retention, gastric retention, or uncontrolled narrow-angle glaucoma. Tolterodine Tartrate Tablets are also contraindicated in patients who have demonstrated hypersensitivity to the drug or its ingredients, or to fesoterodine fumarate extended-release tablets which, like Tolterodine Tartrate Tablets, are metabolized to 5-hydroxymethyl tolterodine. Anaphylaxis and angioedema requiring hospitalization and emergency medical treatment have occurred with the first or subsequent doses of tolterodine tartrate extended-release capsules. In the event of difficulty in breathing, upper airway obstruction, or fall in blood pressure, tolterodine tartrate extended-release capsules should be discontinued and appropriate therapy promptly provided.
QTcF and a population-specific QTcP method were used to correct QT interval for heart rate. No single QT correction method is known to be more valid than others. QT interval was measured manually and by machine, and data from both are presented. Use with caution in patients with myasthenia gravis. Detrusitol can be taken before, after or during a meal. This list is not complete and there are many other drugs that can interact with tolterodine. Tell your doctor about all medications you use. This includes prescription, over the counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.